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Tetanus, Diphtheria and Pertussis (Tdap) Vaccine

Selected References:

  • ACOG Committee Opinion No. 718: Update on immunization and pregnancy: tetanus, diphtheria, and pertussis vaccination. 2017. Obstet Gynecol, 130(3):668-669.
  • American Academy of Pediatrics. Committee on Infectious Diseases. “Red Book”: Report on the Committee on Infectious Diseases.” Elk Grove Village, IL: American Academy of Pediatrics 2021.
  • Arora M, el al. 2021. Vaccines – safety in pregnancy. Best Pract Res Clin Obstet Gynaecol. 76:23-40.
  • Baxter R, et al. 2017. Effectiveness of vaccination during pregnancy to prevent infant pertussis. Pediatrics, 139(5):e2016409.1.
  • Bernstein HH, et al. 2022. Factors Influencing Maternal Antepartum Tdap Vaccination. Matern Child Health J. 2022; 26(12): 2385–2395.
  • 2013. Updated recommendations for use of tetanus toxoid, reduced diphtheria, and acellular pertussis vaccine (Tdap) in pregnant women – Advisory Committee on Immunization Practices (ACIP), 2012. MMWR, 62(07):131-5.
  • Campbell H, et al. 2018. Review of vaccination in pregnancy to prevent pertussis in early infancy. J Med Microbiol, 67(10):1426-1456.
  • DeSilva M, et al. 2016. Tdap vaccination during pregnancy and microcephaly and other structural birth defects in offspring. JAMA, 316(17):1823-1825.
  • DiTosto JD, et al. 2021. Association of Tdap vaccine guidelines with vaccine uptake during pregnancy. 16(7):e0254863.
  • Ezeanolue E, et al. 2020. Best practices guidance of the Advisory Committee on Immunization Practices (ACIP). https://www.cdc.gov/vaccines/hcp/acip-recs/general-recs/index.html. Accessed December 15, 2021.
  • Greenberg V. et al. 2023. Tdap vaccination during pregnancy and risk of chorioamnionitis and related infant outcomes. Vaccine. 41(22):3429-3435.
  • Hassen M, et al. Safety of maternal pertussis vaccination on pregnancy and birth outcomes:  A prospective cohort study. Vaccine, 39(2):324-331.
  • Havers FP, et al. 2020. Use of tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis vaccines: Updated recommendations of the Advisory Committee on Immunization Practices – United States, 2019. MMWR Morb Mortal Wkly Rep, 69(3):77-83.
  • Kerr SM, et al. 2020. Tetanus, diptheria, and pertussis vaccine (Tdap) in pregnancy and risk of major birth defects in the offspring. Birth Defects Res, 112(5):393-403.
  • Kharbanda EO, et al. 2014. Evaluation of the association of maternal pertussis vaccination with obstetric events and birth outcomes. JAMA, 312(18):1897-1904.
  • Khromava A, et al. 2008. Immunization of pregnant women with tetanus-diphtheria-acellular pertussis (Tdap) vaccine: 29 months of data from the ADACEL vaccine pregnancy registry. Pharmacoepidemiol Drug Saf, 17(1): S194-S195.
  • Layton JB, et al. 2017. Prenatal Tdap immunization and risk of maternal and newborn adverse events. Vaccine, pii: S0264-410X(17)30868-X.
  • McMillan M, et al. 2017. Safety of tetanus diphtheria, and pertussis vaccination during pregnancy: a systematic review. Obstet Gynecol, 129(3):560-573.
  • Mooi FR and de Greeff SC. 2007. The case for maternal vaccination against pertussis. Lancet Infect Dis, 7(9):614-624.
  • Morgan JL, et al. 2015. Pregnancy outcomes after antepartum tetanus, diphtheria, and acellular pertussis vaccination. Obstet Gynecol, 125: 1433-1438.
  • Munoz FM, et al. 2014. Safety and immunogenicity of tetanus diphtheria and acellular pertussis (Tdap) immunization during pregnancy in mothers and infants: a randomized clinical trial. JAMA, 311(17):1760-1769.
  • Nascimento RMD, et al. 2021. Protective effect of exclusive breastfeeding and effectiveiness of maternal vaccination in reducing pertussis-like illness. J Pediatr, (Rio J)97:500-507.
  • Nasser R, et al. 2019. Are all vaccines safe for the pregnant traveler? A systematic review and meta- analysis. J Travel Med, doi:10.1093/jtm/taz074.
  • National Center for Immunization and Respiratory Diseases. 2011. General recommendations on immunization — recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR Recomm Rep, 60 (RR02):1-60.
  • Orije MRP, et al. Breast milk antibody levels in Tdap vaccinated women after preterm delivery. Clin Infect Dis, 73:e1305-e1313.
  • Panagiotakopoulos L, et al. 2020. Evaluating the association of stillbirths after maternal vaccination in the Vaccine Safety Datalink. Obstet Gynecol, 136(6):1086-1094.
  • Shakib JH, et al. 2013. Tetanus, Diphtheria, Acellular Pertussis Vaccine during Pregnancy: Pregnancy and Infant Health Outcomes. J Pediatr. 163(5):1422-6.e1-4.
  • Sukumaran L, et al. 2015. Association of Tdap vaccination with acute events and adverse birth outcomes among pregnant women with prior tetanus-containing immunizations. JAMA, 314(15):1581-1587.
  • Sukumaran L, et al. 2015. Safety of tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis and influenza vaccinations in pregnancy. Obstet Gynecol, 126(5):1069-1074.
  • Walls T, et al. 2016. Infant outcomes after exposure to Tdap vaccine in pregnancy: an observational study. BMJ Open, (1):e009536.
  • Winter K, et al. 2012. California pertussis epidemic, 2010. The Journal of Pediatrics, 161(6):1091-1096.
  • Zheteyeva YA, et al. 2012. Adverse event reports after tetanus toxoid reduced diphtheria toxoid and acellular pertussis vaccines in pregnant women. Am J Obstet Gynecol, 207(1):59.e1-59.e7.
  • Zimmermann P, et al. 2019. The effect of maternal immunization during pregnancy on infant vaccine responses. EClinicalMedicine, 13:21-30.

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