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Quetiapine (Seroquel®)

Selected References:

  • Cohen LS, et al. 2018. Risk of major malformations in infants following first trimester exposure to quetiapine. Am J Psychiatry, 175:1225–1231.
  • Damkier P, & Videbech P. 2018. The safety of second‐generation antipsychotics during pregnancy: a clinically focused review. CNS Drugs, 32:351– 366.
  • Ennis ZN., & Damkier P. 2015. Pregnancy exposure to olanzapine, quetiapine, risperidone, aripiprazole and risk of congenital malformations. A systematic review. Basic Clin Pharmacol Toxicol, 116:315-320.
  • FDA Drug Safety Communication: Antipsychotic drug labels updated on use during pregnancy and risk of abnormal muscle movements and withdrawal symptoms in newborns: https://www.fda.gov/drugs/drugsafety/ucm243903.htm.
  • Heinonen E, et al. 2022 Antipsychotic use during pregnancy and risk for gestational diabetes: a national register‑based cohort study in Sweden. CNS Drugs, 36:529–539.
  • Holt RI, & Peveler RC. 2011. Antipsychotics and hyperprolactinaemia: mechanisms, consequences and management. Clin Endocrinol (Oxf); 74(2):141-147.
  • Huybrechts KF, et al. 2016. Antipsychotic use in pregnancy and the risk for congenital malformations. JAMA Psychiatry, 73(9): 938-946.
  • Kulkarni J, et al. 2014. A prospective cohort study of antipsychotic medications in pregnancy: the first 147 pregnancies and 100 one year old babies. PLoS ONE, 9(5):e947-988.
  • Leutritz AL, et al. 2022. Psychotropic medication in pregnancy and lactation and early development of exposed children. British Journal of Clinical Pharmacology, 1-14.
  • Levesque S, & Riley C. 2017. Fetal exposure to lamotrigine and quetiapine in two consecutive pregnancies. Arch Womens Ment Health; 20:237-339.
  • Liu X, et al. 2022. Association of maternal antipsychotic prescription during pregnancy with standardized test scores of schoolchildren in Denmark. JAMA Internal Medicine; 182(10):1035-1043.
  • Lusskin SI, et al. 2004. Prolactin elevation with ziprasidone. Am J Psychiatry; 161(10):1925.
  • Peng M, et al. 2013. Effects of prenatal exposure to atypical antipsychotics on postnatal development and growth of infants: a case-controlled, prospective study. Psychopharmacology; 228:577–584.
  • Shao P, et al. 2015. Effects of clozapine and other atypical antipsychotics on infants development who were exposed to as fetus: a post-hoc analysis. PLoS One; 10(4): 0123373.
  • Sørensen MJ, et al. 2015. Risk of fetal death after treatment with antipsychotic medications during pregnancy. PLoS One; 10: 0132280.
  • Staub L, et al. 2022. Association of antipsychotic drug exposure in pregnancy with risk of neurodevelopmental disorders a national birth cohort study. JAMA Internal Medicine, 182(5):522-533.
  • Wichman CL. 2009. Atypical antipsychotic use in pregnancy: a retrospective review. Arch Womens Ment Health; 12:53–57.
  • Yazdani-Brojeni P, et al. 2018. Quetiapine excretion into human breast milk. J Clin Psychopharmacol; 38:362–364.
  • Zheng L, et al. 2022. Antidepressants and antipsychotics in human pregnancy: transfer across the placenta and opportunities for modeling studies. Journal of Clinical Pharmacology, 62(1):115-128.

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